Drug Profile


Alternative Names: CCX 168

Latest Information Update: 27 Mar 2017

Price : $50

At a glance

  • Originator ChemoCentryx
  • Developer ChemoCentryx; Mario Negri Institute for Pharmacological Research
  • Class Anti-inflammatories; Cyclopentanes; Piperidines; Small molecules
  • Mechanism of Action Complement C5a receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Anti-neutrophil cytoplasmic antibody-associated vasculitis; Glomerulonephritis; Haemolytic uraemic syndrome
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Anti-neutrophil cytoplasmic antibody-associated vasculitis
  • Phase II Haemolytic uraemic syndrome; IgA nephropathy
  • Phase I Autoimmune disorders
  • Clinical Phase Unknown Glomerulonephritis

Most Recent Events

  • 22 Mar 2017 Clinical trials in Glomerulonephritis in USA (PO)
  • 22 Mar 2017 Avacopan receives Orphan Drug status for Glomerulonephritis in USA
  • 13 Mar 2017 ChemoCentryx terminates a phase II trial for Haemolytic uraemic syndrome in Italy, as the trial accomplished its goal with the enrolled six patients (PO) (NCT02464891)
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