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Drug Profile

AMB 051

Alternative Names: AMB 053; AMB-051; AMB-055; AMB-05X; AMG-820

Latest Information Update: 08 Oct 2024

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At a glance

  • Originator Amgen
  • Developer Amgen; AmMax Bio; LifeMax Laboratories
  • Class Antibodies; Antifibrotics; Antineoplastics; Eye disorder therapies; Immunotherapies; Monoclonal antibodies; Urologics
  • Mechanism of Action Macrophage colony-stimulating factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Giant cell tumour of tendon sheath; Idiopathic pulmonary fibrosis
  • Phase I/II Solid tumours
  • Preclinical Autosomal recessive polycystic kidney disease; Diabetic macular oedema; Unspecified; Wet age-related macular degeneration

Most Recent Events

  • 01 Oct 2024 M.D. Anderson Cancer Center plans a phase II trial for Colorectal cancer in USA (IV) in February 2025 (NCT06617858)
  • 03 Jun 2024 AmMax Bio completes a phase II trial for Giant cell tumour of tendon sheath in Australia, Netherlands and USA (EudraCT2022-000101-28) (NCT05349643)
  • 24 May 2024 AmMax Bio terminates a phase II trial in Giant cell tumour of tendon sheath in Germany, Hungary, Poland, Ukraine, Netherlands, Czech Republic (IV) (NCT04938180) (EudraCT2020-004870-22)

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