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Basmisanil - Roche

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Drug Profile

Basmisanil - Roche

Alternative Names: GABRA5 negative allosteric modulator (NAM) - Roche; NTX-1511; RG-1662; RO-5186582

Latest Information Update: 14 Aug 2025

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At a glance

  • Originator Roche
  • Developer Chugai Pharmaceutical; Newleos Therapeutics; Roche
  • Class Antidementias; Oxazoles; Pyridines; Small molecules; Thiamorpholines
  • Mechanism of Action GABA A alpha 5 receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Chromosome disorders
  • Discontinued Down syndrome; Neurological disorders; Schizophrenia

Most Recent Events

  • 06 Aug 2025 Phase-II clinical trials in Chromosome disorders (PO) prior to August 2025 (Newleos Therapeutics pipeline, August 2025)
  • 13 Feb 2025 RO 7308480 licensed to Newleos Therapeutics
  • 04 Mar 2024 Discontinued - Phase-II for Chromosome disorders (In adolescents, In children) in USA, Portugal, Poland (PO) (NCT05307679)

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