Evolocumab

Drug Profile

Evolocumab

Alternative Names: AMG-145; Repatha

Latest Information Update: 22 Mar 2017

Price : $50

At a glance

  • Originator Amgen
  • Developer Amgen; Amgen Astellas BioPharma
  • Class Antihyperlipidaemics; Monoclonal antibodies
  • Mechanism of Action PCSK9 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypercholesterolaemia
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hypercholesterolaemia; Hyperlipoproteinaemia type IIa

Most Recent Events

  • 18 Mar 2017 Interim efficacy, adverse events data from the phase III EBBINGHAUS trial in Hypercholesterolaemia presented at the 66th Annual Scientific Session of the American College of Cardiology (AAC-2017)
  • 17 Mar 2017 Amgen plans a phase III trial for Dyslipidaemia in Europe (NCT03080935)
  • 17 Mar 2017 Interim efficacy, adverse events, pharmacodynamics and immunogenicity data from the phase III FOURIER trial in Hypercholesterolaemia presented at the 66th Annual Scientific Session of the American College of Cardiology (AAC-2017)
Restricted Access

Oops, it looks like you don’t have a valid subscription to this content. To gain full access to the content and functionality of the AdisInsight database try one of the following.

  • with a username/password associated to an account with a valid subscription
  • Contact your organization’s admin about adding this content to your AdisInsight subscription
  • Request a trial

If you are a subscriber to this content then contact us at AsktheExpert.AdisInsight@springer.com so we can help.

Back to top