Lefamulin- Nabriva Therapeutics

Drug Profile

Lefamulin- Nabriva Therapeutics

Alternative Names: BC-3781; BC-3781.Ac; Lefamulin-acetate

Latest Information Update: 06 Dec 2017

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At a glance

  • Originator Nabriva Therapeutics
  • Class Alkenes; Antibacterials; Cyclopentanes; Diterpenes; Polycyclic compounds; Small molecules; Thioglycolates
  • Mechanism of Action Peptidyltransferase modulators; Protein 50S ribosomal subunit modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Community-acquired pneumonia
  • Phase II Skin and soft tissue infections
  • Preclinical Bacterial infections; Bone and joint infections; Nosocomial pneumonia; Osteomyelitis; Sexually transmitted infections

Most Recent Events

  • 04 Dec 2017 Nabriva Therapeutics completes enrolment in the phase III LEAP 2 trial for Community acquired pneumonia in USA, Argentina, Brazil, Bulgaria, Chile, Georgia, Latvia, Mexico, Peru, Philippines, Poland, Romania, Russia, Serbia, South Africa, South Korea, Taiwan and Ukraine (NCT02813694)
  • 15 Nov 2017 Lefamulin is still in preclinical development for Sexually transmitted infections in USA (PO, Tablet) (IV, Infusion) (Nabriva Therapeutics pipeline, November 2017)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Community-acquired-pneumonia(In volunteers) in Austria (IV, Infusion)
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