Drug Profile


Alternative Names: AGS-16C3F; AGS-16M8F; Anti-ENPP3-MMAF

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Agensys
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Renal cell carcinoma

Most Recent Events

  • 26 Apr 2017 Agensys and Astellas Pharma completes a phase I trial for Renal cell carcinoma (Metastatic disease, Second-line therapy or greater) in USA (NCT01672775)
  • 31 Jan 2017 Phase-II clinical trials in Renal cell carcinoma in Europe (IV) (Astellas Pharma pipeline, January 2017)
  • 01 Feb 2016 Phase-II clinical trials in Renal cell carcinoma (Second-line therapy or greater, Metastatic disease) in USA, Canada (IV) (NCT02639182)
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