Drug Profile


Alternative Names: AZD 2014

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator AstraZeneca
  • Developer AstraZeneca; Cambridge University Hospitals; Netherlands Cancer Institute; NHS Greater Glasgow and Clyde; University of Birmingham; University of London; University of Texas M. D. Anderson Cancer Center
  • Class 2 ring heterocyclic compounds; Benzamides; Cytostatics; Morpholines; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action MTORC1 protein inhibitors; MTORC2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Colorectal cancer; Diffuse large B cell lymphoma; Gastric cancer; Meningioma; Non-small cell lung cancer; Ovarian cancer; Solid tumours
  • Phase I/II Breast cancer; Fallopian tube cancer; Glioblastoma; Peritoneal cancer
  • Phase I Prostate cancer
  • No development reported Advanced breast cancer
  • Discontinued Renal cancer

Most Recent Events

  • 29 May 2017 Samsung Medical Center plans a phase II trial for Solid tumours(Refractory metastatic disease, Second-line therapy or greater, Monotherapy) in South Korea (NCT03166176)
  • 29 May 2017 Samsung Medical Center plans the RICTOR_SC phase II trial for Solid tumours (Late-stage disease, Refractory metastatic disease) in South Korea (NCT03166904)
  • 13 Apr 2017 Samsung Medical Center and AstraZeneca plan the SUKSES-D phase III trial for Small cell lung cancer (Monotherapy)(NCT03106155)
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