Drug Profile


Alternative Names: AZD 2014

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator AstraZeneca
  • Developer AstraZeneca; Cambridge University Hospitals; Netherlands Cancer Institute; NHS Greater Glasgow and Clyde; University of Birmingham; University of London; University of Texas M. D. Anderson Cancer Center
  • Class 2 ring heterocyclic compounds; Benzamides; Cytostatics; Morpholines; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action MTORC1 protein inhibitors; MTORC2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Colorectal cancer; Diffuse large B cell lymphoma; Gastric cancer; Meningioma; Non-small cell lung cancer; Ovarian cancer; Solid tumours
  • Phase I/II Breast cancer; Fallopian tube cancer; Glioblastoma; Peritoneal cancer
  • Phase I Prostate cancer
  • No development reported Advanced breast cancer
  • Discontinued Renal cancer

Most Recent Events

  • 09 Mar 2017 Massachusetts General Hospital, National Cancer Institute and AstraZeneca plan a phase II trial for Meningioma (Recurrent; Second-line therapy or greater) in USA (NCT03071874)
  • 01 Feb 2017 Samsung Medical Center initiates enrolment in a phase II trial for Gastric cancer (Second-line therapy or greater) in South Korea (NCT03082833)
  • 01 Feb 2017 Phase-II clinical trials in Gastric cancer (Second-line therapy or greater) in South Korea (PO) (NCT03061708)
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