Drug Profile


Alternative Names: AZD 2014

Latest Information Update: 12 Oct 2017

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At a glance

  • Originator AstraZeneca
  • Developer AstraZeneca; Cambridge University Hospitals; Massachusetts General Hospital; National Cancer Institute (USA); Netherlands Cancer Institute; NHS Greater Glasgow and Clyde; Samsung Medical Center; University of Birmingham; University of London; University of Texas M. D. Anderson Cancer Center
  • Class 2 ring heterocyclic compounds; Benzamides; Cytostatics; Morpholines; Pyridines; Pyrimidines; Small molecules
  • Mechanism of Action MTORC1 protein inhibitors; MTORC2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Colorectal cancer; Diffuse large B cell lymphoma; Gastric cancer; Meningioma; Non-small cell lung cancer; Ovarian cancer; Small cell lung cancer; Solid tumours
  • Phase I/II Breast cancer; Fallopian tube cancer; Glioblastoma; Peritoneal cancer
  • Phase I Prostate cancer
  • Discontinued Renal cancer

Most Recent Events

  • 27 Sep 2017 Phase-II clinical trials in Meningioma (Second-line therapy or greater, Recurrent) in USA (PO) (NCT03071874)
  • 02 Aug 2017 Phase-II clinical trials in Small cell lung cancer (Monotherapy, Second-line therapy or greater) in South Korea (PO) (NCT03106155)
  • 06 Jul 2017 AstraZeneca completes a phase I trial for Solid tumours (Monotherapy, Combination therapy, Late-stage disease, Second-line therapy or greater) in United Kingdom (NCT02640755)
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