Alirocumab - Regeneron/Sanofi

Drug Profile

Alirocumab - Regeneron/Sanofi

Alternative Names: ALI; Anti-PCSK9 monoclonal antibody; Anti-proprotein convertase subtilisin kexin type 9 monoclonal antibody; Praluent; REGN-727; SAR-236553

Latest Information Update: 28 Nov 2017

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At a glance

  • Originator Regeneron Pharmaceuticals; sanofi-aventis
  • Developer Regeneron Pharmaceuticals; Sanofi; University Hospital Inselspital
  • Class Antihyperlipidaemics; Monoclonal antibodies
  • Mechanism of Action PCSK9 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hyperlipoproteinaemia type IIa
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hypercholesterolaemia; Hyperlipoproteinaemia type IIa
  • Phase III Coronary artery disease

Most Recent Events

  • 11 Nov 2017 Efficacy and adverse events data from the phase III ODYSSEY OLE trial presented at the 90th Annual Scientific Sessions of the American Heart Association (AHA-2017)
  • 11 Nov 2017 Pooled efficacy data from the phase III ODYSSEY trials in Hpercholesterolaemia presented at the 90th Annual Scientific Sessions of the American Heart Association (AHA-2017)
  • 08 Nov 2017 Phase-III clinical trials in Hyperlipoproteinaemia type IIa (In adolescents, In adults, In the elderly) in Austria, Germany and Greece (SC) (EudraCT 2017-000351-95) (NCT03156621)
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