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Capmatinib - Novartis Oncology

Drug Profile

Capmatinib - Novartis Oncology

Alternative Names: INC-280; INCB-028060; INCB-28060; TABRECTA; Tabrecta

Latest Information Update: 14 Dec 2023

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At a glance

  • Originator Incyte Corporation
  • Developer Array BioPharma; Novartis Oncology
  • Class Antineoplastics; Benzamides; Fluorobenzenes; Heterocyclic bicyclo compounds; Imidazoles; Quinolines; Small molecules; Triazines
  • Mechanism of Action Proto-oncogene protein c-met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase II Glioblastoma; Liver cancer; Malignant melanoma; Renal cell carcinoma; Solid tumours
  • Phase I/II Breast cancer; Colorectal cancer; Head and neck cancer
  • No development reported Triple negative breast cancer

Most Recent Events

  • 31 Oct 2023 Novartis completes the phase-III GeoMETry-III trial in Non-small cell lung cancer in Belgium, Germany, Brazil, Bulgaria, France, India, Italy, South Korea, Netherlands, Hungary, Lithuania, Portugal and Spain (PO) (NCT04427072) (EudraCT2020-001578-31)
  • 20 Oct 2023 Efficacy and adverse event data from a phase III GeoMETry-III trial in Non-small cell lung cancer presented at the 48th European Society for Medical Oncology Congress (ESMO-2023)
  • 03 Oct 2023 Phase-II clinical trials in Non-small cell lung cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (PO) (NCT05567055)
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