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Research programme: ERN1 protein inhibitors - MannKind Corporation

Drug Profile

Research programme: ERN1 protein inhibitors - MannKind Corporation

Alternative Names: Inositol requiring enzyme-1 inhibitor; IRE-1α inhibitor; MKC 204; Mkc 8866; MKC-3946

Latest Information Update: 28 Jul 2021

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At a glance

  • Originator MannKind Corporation
  • Class Antineoplastics; Small molecules
  • Mechanism of Action ERN1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Multiple myeloma; Precursor cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 28 Jul 2021 No recent reports of development identified for preclinical development in Precursor-cell-lymphoblastic-leukaemia-lymphoma in USA
  • 05 Dec 2020 Interim pharmacodynamics data from a preclinical study in in Precursor cell lymphoblastic leukaemia-lymphoma presented at the 62nd Annual Meeting and Exposition of the American Society of Hematology
  • 22 Jun 2017 Preclinical trials in Acute lymphoblastic leukaemia in USA (unspecified route)
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