Drug Profile


Alternative Names: 1024; 992; 992/1024; Anti epidermal growth factor receptor monoclonal antibody - Symphogen; Anti-EGFR-monoclonal-antibody-Symphogen; DS 992/DS 1024; Modotuximab/futuximab; Sym-004

Latest Information Update: 10 Mar 2017

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At a glance

  • Originator Symphogen
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Epidermal growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Colorectal cancer; Glioma
  • Phase I Non-small cell lung cancer; Oesophageal cancer
  • No development reported Head and neck cancer

Most Recent Events

  • 23 Feb 2017 Symphogen withdraws prior to enrolment a phase I/II trial in Non-small cell lung cancer (Combination therapy, Metastatic disease, Late-stage disease, Second-line therapy or greater) in USA (IV) (NCT02924233)
  • 18 Jan 2017 Symphogen withdraws a phase II trial prior to enrolment due to a business decision in Colorectal cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in Spain, USA and Italy (IV) (NCT02965417)
  • 14 Nov 2016 Symphogen plans a phase II trial for Colorectal cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA, Italy and Spain (IV) (NCT02965417)
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