Research programme: Dual-Affinity Re-Targeting anticancer therapeutics - MacroGenics

Drug Profile

Research programme: Dual-Affinity Re-Targeting anticancer therapeutics - MacroGenics

Alternative Names: 5T4 x CD3 DART; DART candidates - MacroGenics/Pfizer; DART Oncology; EphA2xCD3 DART; IL1Ra2xCD3 DART; JNJ-9383; MGD 015; MGD 019; MGD-15; PD-1 x CTLA-4 bispecific DART molecule; ROR1xCD3 DART

Latest Information Update: 28 Apr 2017

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At a glance

  • Originator MacroGenics
  • Class Antineoplastics; Bispecific antibodies; Proteins
  • Mechanism of Action CD3 antigen modulators; Interleukin 13 receptor modulators; Receptor tyrosine kinase-like orphan receptor modulators; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Cancer

Most Recent Events

  • 08 Nov 2017 MacroGenics announces intention to submit IND application to the US FDA for MGD 019 in Cancer in 2018
  • 31 Aug 2017 Janssen plans a first-in-human phase I trial of MGD 015 for Cancer in 2018
  • 01 Apr 2017 Pharmacokinetics data from preclinical studies in Cancer presented at the 108th Annual Meeting of the American Association for Cancer Research (AACR-2017)
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