Drug Profile

Leflutrozole - ReproNovo

Alternative Names: BGS-649; RPN-001

Latest Information Update: 27 Apr 2026

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At a glance

Originator Novartis
Developer Mereo BioPharma; Novartis; ReproNovo
Class Antihormones; Benzonitrile; Small molecules; Triazoles
Mechanism of Action Aromatase inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes

Highest Development Phases

Phase II Hypogonadism
Discontinued Endometriosis

Most Recent Events

27 Jun 2025 Phase-II clinical trials in Hypogonadism (In adults) in USA (PO) (NCT06993155)
28 May 2025 ReproNovo plans phase-II ETNA trial for Hypogonadism (In adults) in June 2025 (PO, Capsule) (NCT06993155)
08 Jan 2024 Leflutrozole licensed to ReproNovo, prior to January 2024

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