Drug Profile


Alternative Names: MORAb-004; Ontecizumab

Latest Information Update: 15 Sep 2017

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At a glance

  • Originator Ludwig Institute for Cancer Research; Morphotek
  • Developer Morphotek; National Cancer Institute (USA)
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD248 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Soft tissue sarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Colorectal cancer; Malignant melanoma; Soft tissue sarcoma
  • Phase I Lymphoma; Solid tumours

Most Recent Events

  • 15 Sep 2017 Phase-II development for Soft tissue sarcoma is ongoing in Australia, European Union, New Zealand and USA (IV) (Morphotek pipeline, September 2017)
  • 01 Oct 2016 Eisai completes a phase I trial in Solid tumours (Monotherapy, Second-line therapy or greater) in Japan (NCT01773434)
  • 01 Aug 2016 Morphotek completes a phase II trial in Soft tissue sarcoma (Combination therapy, Metastatic disease) in USA, Australia, Belgium, France, Italy and the Netherlands (NCT01574716)
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