Drug Profile


Alternative Names: BYM-338

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator MorphoSys; Novartis
  • Developer Novartis
  • Class Monoclonal antibodies
  • Mechanism of Action Type II-B activin receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Inclusion body myositis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cachexia; Muscular atrophy; Type 2 diabetes mellitus
  • Discontinued Inclusion body myositis

Most Recent Events

  • 09 Jun 2017 Adverse events and pharmacodynamics data from a clinical trial in Healthy volunteers presented at the 77th Annual Scientific Sessions of the American Diabetes Association (ADA-2017)
  • 13 Feb 2017 Novartis completes a phase IIb/III extension trial for Inclusion body myositis (In adults, In the elderly) in USA, Australia, Japan, Belgium, Denmark, Italy, Netherlands, United Kingdom, Switzerland and France (IV) (NCT02573467)
  • 27 Jan 2017 Discontinued - Phase-III for Inclusion body myositis (In the elderly, In adults) in Belgium, Denmark, Italy, Japan, Netherlands, United Kingdom, France, Germany, Poland, Switzerland, Australia, USA (IV) (Novartis 20-F filed in 2017)
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