Drug Profile


Alternative Names: AB-0024; Anti-LOXL2 monoclonal antibody; GS-6624

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Arresto Biosciences
  • Developer Gilead Sciences
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Chemokine CXCL12 inhibitors; Connective tissue growth factor inhibitors; LOXL2 protein-inhibitors; Transforming growth factor beta1 inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Primary sclerosing cholangitis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hepatic fibrosis; Liver cirrhosis; Non-alcoholic steatohepatitis; Primary sclerosing cholangitis
  • Discontinued Colorectal cancer; Idiopathic pulmonary fibrosis; Myelofibrosis; Pancreatic cancer

Most Recent Events

  • 20 Apr 2017 Interim efficacy data from a phase IIb trial in Non-alcoholic steatohepatitis released by Gilead Sciences
  • 27 Jan 2017 Gilead Sciences terminates phase IIb trial in Cirrhosis in France, Italy, USA, Canada, Germany, Puerto Rico and Spain (IV) (NCT01672879)
  • 27 Jan 2017 Gilead Sciences terminates phase IIb trial in Non-alcoholic steatohepatitis in USA, Belgium, Canada, France, Germany, Italy, Puerto Rico, Spain and United Kingdom (SC) (NCT01672866)
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