Drug Profile


Alternative Names: AB-0024; Anti-LOXL2 monoclonal antibody; GS-6624

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Arresto Biosciences
  • Developer Gilead Sciences
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Chemokine CXCL12 inhibitors; Connective tissue growth factor inhibitors; LOXL2 protein-inhibitors; Transforming growth factor beta1 inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Primary sclerosing cholangitis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hepatic fibrosis; Liver cirrhosis; Non-alcoholic steatohepatitis; Primary sclerosing cholangitis
  • Discontinued Colorectal cancer; Idiopathic pulmonary fibrosis; Myelofibrosis; Pancreatic cancer

Most Recent Events

  • 20 Apr 2017 Interim efficacy data from a phase IIb trial in Non-alcoholic steatohepatitis released by Gilead Sciences
  • 19 Apr 2017 Efficacy and safety data from phase IIb trial in Primary sclerosing cholangitis presented at The International Liver Congress 2017 (ILC-2017)
  • 19 Apr 2017 Efficacy and safety data from two phase IIb trial in Nonalcoholic steatohepatitis and Cirrhosis presented at The International Liver Congress 2017 (ILC-2017)
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