Drug Profile


Alternative Names: Abrilimumab; AMG-181; Anti-α4β7 integrin monoclonal antibody; MEDI-7183

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Amgen
  • Class Anti-inflammatories; Monoclonal antibodies
  • Mechanism of Action Alpha4-beta7 integrin antagonists; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Crohn's disease; Ulcerative colitis

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 28 Jul 2015 Phase-II development in Crohn's disease and Ulcerative colitis is ongoing worldwide
  • 19 Jun 2015 Amgen completes enrolment in its phase II trial for Crohn's disease in USA, Canada, European Union and Switzerland (NCT01696396)
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