BL 8040

Drug Profile

BL 8040

Alternative Names: 4F-Benzoyl-TN14003; BKT-140; BL-8040; TF-14016; TN-14003

Latest Information Update: 24 Aug 2017

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At a glance

  • Originator Kyoto University
  • Developer Biokine Therapeutics; BioLineRx; Genentech; Merck AG; University of Texas M. D. Anderson Cancer Center
  • Class Antianaemics; Antineoplastics; Peptides
  • Mechanism of Action Apoptosis stimulants; Cell movement activators; CXCR4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Stem cell mobilisation
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia; Pancreatic cancer; Stem cell mobilisation
  • Phase I/II Aplastic anaemia; Multiple myeloma; Myelodysplastic syndromes
  • Preclinical Autoimmune disorders; Chronic myeloid leukaemia; Gastric cancer; Non-small cell lung cancer; Thrombocytopenia

Most Recent Events

  • 20 Sep 2017 Roche plans the phase Ib/II UMBRELLA trial for Gastric cancer (Combination therapy, Late stage disease, Metastatic disease, Inoperable/Unresectable) in the US, UK, Netherlands, France, Germany, South Korea, Spain and Taiwan (NCT03281369)
  • 21 Aug 2017 BioLineRx completed regulatory submissions for initiation of the phase III GENESIS study in Stem cell mobilisation for autologous bone-marrow transplantation in patients with multiple myeloma
  • 16 Aug 2017 BioLineRx terminates a phase II trial in Acute myeloid leukaemia (Second-line therapy or greater) in Germany (SC) (EudraCT2014-002702-21) (NCT02502968)
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