Drug Profile


Alternative Names: BMS-936564; MDX-1338

Latest Information Update: 07 Apr 2017

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At a glance

  • Originator Medarex
  • Developer Bristol-Myers Squibb; Medarex
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CXCR4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Acute myeloid leukaemia; Solid tumours
  • No development reported Acute lymphoblastic leukaemia; B cell lymphoma; B cell prolymphocytic leukaemia; Multiple myeloma

Most Recent Events

  • 29 Jun 2017 Bristol-Myers Squibb and Dana-Farber Cancer Institute plan a phase I/II trial in Waldenstrom's macroglobulinaemia (Combination therapy, Second-line therapy or greater) (IV) (NCT03225716)
  • 09 Mar 2017 Bristol-Myers Squibb terminates a phase I/II trial for Solid tumours (Combination therapy, Late-stage disease, Metastatic disease) in USA, Finland due to lack of efficacy in the short term acute phase (NCT02472977)
  • 15 Dec 2016 Biomarkers information updated
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