Drug Profile


Alternative Names: Anti-HER3/EGFR DAF; MEHD-7945A; RG 7597; RO-5541078

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Genentech; Roche
  • Developer Genentech
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Epidermal growth factor receptor antagonists; ERBB-3 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours
  • Discontinued Colorectal cancer; Head and neck cancer

Most Recent Events

  • 22 Jun 2017 Genentech completes a phase Ib trial in Head and neck cancer (recurrent/metastatic disease, combination therapy) in USA & Belgium (NCT01911598)
  • 30 Jun 2016 Genentech completes a phase I trial for Solid tumours (Combination therapy) in USA and Spain (NCT01986166)
  • 28 Jan 2015 Discontinued - Phase-I for Head and neck cancer (Combination therapy, Metastatic disease, Recurrent) in Belgium (IV)
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