Research programme: protease-activated monoclonal antibodies - CytomX Therapeutics

Drug Profile

Research programme: protease-activated monoclonal antibodies - CytomX Therapeutics

Alternative Names: CTLA-4 Probody Tx; CTLA-4-directed Probody™; CTX-023; CTX-033; CTX-1003; CX 188; CX 2005; EGFR Probody Drug Conjugate; J43 antibody; Probodies; Probody™ cancer therapeutics - Bristol-Myers Squibb

Latest Information Update: 29 Nov 2017

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At a glance

  • Originator CytomX Therapeutics
  • Developer Bristol-Myers Squibb; CytomX Therapeutics
  • Class Drug conjugates; Monoclonal antibodies
  • Mechanism of Action Cytotoxic T-lymphocyte antigen 4 inhibitors; Epidermal growth factor receptor antagonists; Immunomodulators; Notch signalling pathway inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Cancer
  • No development reported Autoimmune disorders
  • Discontinued Inflammation

Most Recent Events

  • 28 Nov 2017 US FDA accepts IND application for CTLA-4-directed Probody™ for Cancer
  • 13 Nov 2017 CX 188 is still in preclinical development for Cancer in USA (Cytomx pipeline, November 2017)
  • 07 Nov 2017 CytomX plans to file an IND application with the US FDA of CX 188 in USA in the second half of 2018
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