Research programme: purinoceptor P2Z antagonists - Affectis/Merck Serono

Drug Profile

Research programme: purinoceptor P2Z antagonists - Affectis/Merck Serono

Alternative Names: AFC-5128; AFC-5261

Latest Information Update: 21 Oct 2015

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At a glance

  • Originator Affectis Pharmaceuticals
  • Developer Affectis Pharmaceuticals; Charcot-Marie-Tooth Association; Merck Serono
  • Class
  • Mechanism of Action Purinergic P2X7 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Charcot-Marie-Tooth disease; Multiple sclerosis; Neuropathic pain

Most Recent Events

  • 21 Oct 2015 Preclinical development is ongoing in Germany
  • 21 Apr 2015 Affectis Pharmaceuticals and Charcot Marie Tooth Association agree to co-develop purinoceptor P2Z antagonists in Germany for Charcot-Marie-Tooth disease
  • 21 Apr 2015 Preclinical trials in Charcot-Marie-Tooth disease in Germany (PO)
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