Talazoparib

Drug Profile

Talazoparib

Alternative Names: BMN-673; LT 006673; LT-00673; LT-673; MDV-3800; Talazoparib tosylate

Latest Information Update: 15 Jun 2017

Price : $50

At a glance

  • Originator LEAD Therapeutics
  • Developer BioMarin Pharmaceutical; Medivation; National Cancer Institute (USA); St. Jude Childrens Research Hospital; University of California at San Francisco; University of Maryland Greenbaum Cancer Center; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Fluorobenzenes; Phthalazines; Pyridines; Small molecules; Triazoles
  • Mechanism of Action Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II Cancer; Ovarian cancer; Prostate cancer; Solid tumours
  • Phase I/II Acute myeloid leukaemia
  • Phase I Ewing's sarcoma; Pancreatic cancer; Small cell lung cancer
  • Preclinical Glioblastoma; Non-small cell lung cancer
  • Discontinued Haematological malignancies

Most Recent Events

  • 03 Jun 2017 Efficacy and safety data from the phase II ABRAZO trial in Breast cancer released by Pfizer
  • 03 Jun 2017 Pfizer completes enrolment in its phase III EMBRACA trial for breast cancer in USA, Australia, Belgium, France, South Korea, Spain, Taiwan and the UK
  • 02 Jun 2017 Medivation completes the phase II ABRAZO trial in Breast cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in Germany, France, Spain, United Kingdom, USA (PO) (NCT02034916) prior to June 2017
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