Talazoparib

Drug Profile

Talazoparib

Alternative Names: BMN-673; LT 006673; LT-00673; LT-673; MDV-3800; Talazoparib tosylate

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator LEAD Therapeutics
  • Developer BioMarin Pharmaceutical; Medivation; National Cancer Institute (USA); St. Jude Childrens Research Hospital; University of California at San Francisco; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Fluorobenzenes; Phthalazines; Pyridines; Small molecules; Triazoles
  • Mechanism of Action Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II Cancer; Ovarian cancer; Prostate cancer; Solid tumours
  • Phase I Ewing's sarcoma; Pancreatic cancer; Small cell lung cancer
  • Preclinical Acute myeloid leukaemia; Glioblastoma; Non-small cell lung cancer
  • Discontinued Haematological malignancies

Most Recent Events

  • 01 Mar 2017 Medivation initiates enrolment in a phase I trial for Solid tumours (Late-stage disease) in Hungary and Moldova (NCT03077607)
  • 01 Jan 2017 Phase-I clinical trials in Solid tumours (Late-stage disease) in Moldova (PO) (NCT03077607)
  • 28 Dec 2016 Phase-II clinical trials in Prostate cancer (Metastatic disease, Second-line therapy or greater, Hormone refractory) in Spain (PO) (EudraCT2016-002036-32)
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