Talazoparib - Medivation

Drug Profile

Talazoparib - Medivation

Alternative Names: BMN-673; BMN-673ts; LT 006673; LT-00673; LT-673; MDV-3800; Talazoparib tosylate

Latest Information Update: 13 Dec 2017

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At a glance

  • Originator LEAD Therapeutics
  • Developer BioMarin Pharmaceutical; Medivation; National Cancer Institute (USA); Pfizer; St. Jude Childrens Research Hospital; University of California at San Francisco; University of Maryland Greenbaum Cancer Center; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Fluorobenzenes; Phthalazines; Pyridines; Small molecules; Triazoles
  • Mechanism of Action Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II Cancer; Ovarian cancer; Prostate cancer; Solid tumours
  • Phase I/II Acute myeloid leukaemia
  • Phase I Ewing's sarcoma; Pancreatic cancer; Small cell lung cancer
  • Preclinical Glioblastoma; Non-small cell lung cancer
  • Discontinued Haematological malignancies

Most Recent Events

  • 08 Dec 2017 Adverse events and efficacy data from the phase III EMBRACA trial in Breast cancer released by Pfizer (NCT01945775)
  • 23 Nov 2017 Pfizer plans a phase I trial for Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater) in Japan in January 2018 (NCT03343054)
  • 26 Oct 2017 Interim efficacy and adverse events data from phase II trial in Cancer presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2017 (AACR-NCI-EORTC - 2017)
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