Drug Profile


Alternative Names: LDK-378; NVP-LDK 378; NVP-LDK378-NX; Zykadia

Latest Information Update: 15 Feb 2017

Price : $50

At a glance

  • Originator Novartis
  • Developer Novartis; University of Texas Southwestern Medical Center
  • Class Antineoplastics; Diamines; Piperidines; Pyrimidines; Small molecules; Sulfones
  • Mechanism of Action Anaplastic lymphoma kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase II Gastrointestinal cancer; Haematological malignancies; Solid tumours; Thyroid cancer

Most Recent Events

  • 31 Jan 2017 The Duke University Medical Center and Novartis withdrew a phase II trial prior to enrolment due to no accrual due to rarity of disease in Haematological malignancies (Second line therapy or greater) in USA (NCT02343679)
  • 06 Dec 2016 Interim pharmacokinetics and adverse event data from a phase I trial in non-small cell lung cancer released by Novartis
  • 06 Dec 2016 Updated efficacy and safety data from a phase III ASCEND-4 trial in non-small cell lung cancer presented at 17th World Conference on Lung Cancer (WCLC-2016)
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