Ceritinib

Drug Profile

Ceritinib

Alternative Names: LDK-378; NVP-LDK 378; NVP-LDK378-NX; Zykadia

Latest Information Update: 28 Dec 2016

Price : $50

At a glance

  • Originator Novartis
  • Developer Novartis; University of Texas Southwestern Medical Center
  • Class Antineoplastics; Diamines; Piperidines; Pyrimidines; Small molecules; Sulfones
  • Mechanism of Action Anaplastic lymphoma kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase II Gastrointestinal cancer; Haematological malignancies; Solid tumours; Thyroid cancer

Most Recent Events

  • 06 Dec 2016 Interim pharmacokinetics and adverse event data from a phase I trial in non-small cell lung cancer released by Novartis
  • 06 Dec 2016 Updated efficacy and safety data from a phase III ASCEND-4 trial in non-small cell lung cancer presented at 17th World Conference on Lung Cancer (WCLC-2016)
  • 09 Oct 2016 Efficacy data from the phase II ASCEND-3 and and phase III ASCEND-5 trial in Non small cell lung cancer presented at 41st European Society for Medical Oncology Congress (ESMO-2016)
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