Drug Profile


Alternative Names: ESBA-1008; RTH-258

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator ESBATech
  • Developer Alcon
  • Class Antibodies; Eye disorder therapies; Immunoglobulin Fv fragments; Monoclonal antibodies
  • Mechanism of Action Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Diabetic macular oedema; Wet age-related macular degeneration

Most Recent Events

  • 03 Apr 2017 Novartis intends to submit NDA to the US FDA for Diabetic macular oedema in 2020
  • 01 Dec 2016 Phase-III clinical trials in Diabetic macular oedema in USA (Intravitreous) (Novartis 20-F 2016)
  • 01 Sep 2016 Alcon completes a phase II trial for Wet age-related macular degeneration in USA (NCT02507388)
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