NSI 189 - Neuralstem

Drug Profile

NSI 189 - Neuralstem

Alternative Names: NSI-189; NSI-189 phosphate

Latest Information Update: 08 Sep 2017

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At a glance

  • Originator Neuralstem
  • Developer Neuralstem; University of California, San Diego
  • Class Antidepressants; Piperazines; Pyridines; Small molecules
  • Mechanism of Action Neurogenesis stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Major depressive disorder
  • Preclinical Alzheimer's disease; Angelman syndrome; Brain injuries; Cognition disorders; Diabetic neuropathies; Neurodegenerative disorders; Post-traumatic stress disorders; Stroke

Most Recent Events

  • 07 Sep 2017 Neuralstem receives patent allowance for NSI-189 in USA
  • 25 Jul 2017 The primary endpoint was not met in a phase II trial in Major Depressive Disorder
  • 28 Feb 2017 Pharmacodynamics data from a preclinical trial in Stroke released by Neuralstem
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