Drug Profile


Alternative Names: GDC 0032; RG-7604

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech; Netherlands Cancer Institute
  • Class 3-ring heterocyclic compounds; Amides; Antineoplastics; Benzazepines; Oxazepines; Pyrazoles; Small molecules; Triazoles
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II/III Non-small cell lung cancer
  • Phase I/II Gynaecological cancer
  • Phase I Solid tumours

Most Recent Events

  • 24 Jul 2017 Genentech and Vanderbilt-Ingram Cancer Center re initiates a phase Ib/II trial in Breast cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA (NCT02457910)
  • 02 Jun 2017 Southwest Oncology Group terminates a phase II trial in Squamous cell lung cancer in USA due to interim results
  • 02 Jun 2017 Efficacy and adverse events data from a phase Ib trial in Breast cancer presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
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