PRI 724

Drug Profile

PRI 724

Alternative Names: PRI-724

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator PRISM BioLab; University of Southern California
  • Developer inVentiv Health; PRISM Pharma Co; Tokyo Metropolitan Komagome Hospital
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Beta catenin inhibitors; CREB-binding protein inhibitors; Wnt signalling pathway inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Acute myeloid leukaemia; Chronic myeloid leukaemia
  • Phase I Hepatic fibrosis; Pancreatic cancer; Solid tumours

Most Recent Events

  • 13 Apr 2017 University of Southern California withdraws prior to enrolment the phase II PREMIER trial for Colorectal cancer in USA (NCT02413853)
  • 30 Dec 2016 Prism Pharma completes a phase I/II trial in Acute myeloid leukaemia (Second-line therapy or greater) and Chronic myeloid leukaemia (Second-line therapy or greater) in USA (NCT01606579)
  • 15 Dec 2016 Biomarkers information updated
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