Drug Profile


Alternative Names: AZD-1722; RDX-5791; Tenapanor hydrochloride

Latest Information Update: 09 Feb 2017

Price : $50

At a glance

  • Originator Ardelyx
  • Developer Ardelyx; AstraZeneca
  • Class Benzylisoquinolines; Gastrokinetics; Irritable bowel syndrome therapies; Small molecules; Sulfonamides
  • Mechanism of Action Fibroblast growth factor 23 expression inhibitors; Sodium-hydrogen exchanger 3 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hyperphosphataemia; Irritable bowel syndrome
  • Phase II Renal failure
  • No development reported Heart failure

Most Recent Events

  • 01 Dec 2016 Ardelyx completes a phase IIb trial in Hyperphosphataemia in USA (NCT02675998)
  • 19 Oct 2016 Phase-III clinical trials in Hyperphosphataemia (in patients with end-stage renal disease) in USA (PO) before October 2016
  • 19 Oct 2016 Adverse events and efficacy data from a phase IIb trial in Irritable bowel syndrome (constipation predominant) released by Ardelyx
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