Polatuzumab vedotin

Drug Profile

Polatuzumab vedotin

Alternative Names: ACD79B-VCMMAE; DCDS-4501A; FCU-2711; RG-7596; RO-5541077; RO-5541077-000

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Genentech
  • Developer Chugai Pharmaceutical; Genentech
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Diffuse large B cell lymphoma; Non-Hodgkin's lymphoma
  • Phase I/II Follicular lymphoma
  • Phase I Chronic lymphocytic leukaemia

Most Recent Events

  • 12 Sep 2017 Roche plans a phase III trial for Diffuse large B-cell lymphoma(Combination therapy; First-line therapy) in USA (NCT03274492)
  • 30 Jun 2017 Polatuzumab vedotin receives Priority Medicine (PRIME) status for Diffuse large B cell lymphoma in European Union
  • 22 Jun 2017 Updated safety and efficacy data from a phase I/II trial in B-cell lymphoma presented at the 22nd Congress of the European Haematology Association (EHA-2017)
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