Drug Profile


Alternative Names: EZN-2279; PEG-rADA; Pegademase recombinant - Leadiant Biosciences; Pegylated recombinant adenosine deaminase; Polyethylene glycol recombinant adenosine deaminase; STM-279

Latest Information Update: 06 Mar 2017

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At a glance

  • Originator Sigma-Tau Pharmaceuticals
  • Developer Leadiant Biosciences; Teijin Pharma
  • Class Antivirals; Polyethylene glycols
  • Mechanism of Action Adenosine deaminase stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Immunodeficiency disorders; Adenosine deaminase deficiency
  • New Molecular Entity No

Highest Development Phases

  • Phase III Adenosine deaminase deficiency; Immunodeficiency disorders

Most Recent Events

  • 28 Feb 2017 Sigma-Tau Pharmaceuticals is now called Leadiant Biosciences
  • 16 Feb 2016 Phase-III clinical trials in Adenosine deaminase deficiency in Japan (IM) (JapicCTI-163204)
  • 07 May 2015 Phase-III development is still ongoing for adenosine deaminase deficiency in USA
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