Drug Profile


Alternative Names: Anti-CSF-1R-monoclonal-antibody-ImClone; IMCCS4; LY-3022855

Latest Information Update: 25 Jul 2017

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At a glance

  • Originator ImClone Systems
  • Developer AstraZeneca; Dana-Farber Cancer Institute; Eli Lilly; ImClone Systems
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Macrophage colony-stimulating factor receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Malignant melanoma
  • Phase I Breast cancer; Prostate cancer; Solid tumours

Most Recent Events

  • 06 Jun 2017 Phase-I/II clinical trials in Malignant melanoma (Late-stage disease, Combination therapy, Metastatic disease, Inoperable/Unresectable) in USA (IV) (NCT03101254)
  • 19 May 2017 Sidney Kimmel Comprehensive Cancer Center plans a phase I trial for Pancreatic cancer (Combination therapy) in USA (NCT03153410)
  • 11 Apr 2017 Eli Lilly in collaboration with Dana-Farber Cancer Institute plans a phase I/II trial for Malignant melanoma in USA (NCT03101254)
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