Abemaciclib

Drug Profile

Abemaciclib

Alternative Names: Abemaciclib mesylate; Bemaciclib; Bemaciclib mesylate; CDK 4/6 dual inhibitor - Eli Lilly; Cyclin dependent kinase 4/6 dual inhibitor - Eli Lilly; LY-2835219

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Eli Lilly
  • Developer Dana-Farber Cancer Institute; Eli Lilly; Emory University; Memorial Sloan-Kettering Cancer Center; Merck Sharp & Dohme
  • Class Aminopyridines; Antineoplastics; Benzimidazoles; Piperazines; Pyrimidines; Small molecules
  • Mechanism of Action Cyclin-dependent kinase 4 inhibitors; Cyclin-dependent kinase 6 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Breast cancer
  • Phase III Non-small cell lung cancer
  • Phase II Brain cancer; Cancer; Glioblastoma; Liposarcoma; Mantle-cell lymphoma; Pancreatic cancer
  • Preclinical Solid tumours

Most Recent Events

  • 07 Aug 2017 Phase-I clinical trials in Cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in China (PO) (NCT02919696)
  • 13 Jul 2017 Phase-II clinical trials in Brain cancer (Recurrent, Second-line therapy or greater) in USA (PO) (NCT03220646)
  • 10 Jul 2017 Preregistration for Breast cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA (PO)
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