Drug Profile


Alternative Names: Abemaciclib mesylate; Bemaciclib; Bemaciclib mesylate; CDK 4/6 dual inhibitor - Eli Lilly; Cyclin dependent kinase 4/6 dual inhibitor - Eli Lilly; Cyclin-dependent-kinase-inhibitors-Eli-Lilly; LY-2835219

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Eli Lilly
  • Developer Eli Lilly; Emory University; Memorial Sloan-Kettering Cancer Center; Merck Sharp & Dohme
  • Class Aminopyridines; Antineoplastics; Benzimidazoles; Piperazines; Pyrimidines; Small molecules
  • Mechanism of Action Cyclin D1 inhibitors; Cyclin-dependent kinase 4 inhibitors; Cyclin-dependent kinase 6 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer; Non-small cell lung cancer
  • Phase II Cancer; Glioblastoma; Liposarcoma; Mantle-cell lymphoma; Pancreatic cancer
  • Preclinical Solid tumours

Most Recent Events

  • 18 May 2017 Eli Lilly plans a phase III trial for Breast cancer (Adjuvant therapy, Early-stage disease) (NCT03155997)
  • 02 May 2017 Dana-Farber Cancer Institute and Eli Lilly plan a phase II trial for Breast cancer (Metastatic disease, Recurrent, Inoperable/Unresectable, Late-stage disease) in USA (NCT03130439)
  • 24 Apr 2017 Eli Lilly intends to make regulatory submissions for Breast cancer based on MONARCH 3 trial
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