Atezolizumab

Drug Profile

Atezolizumab

Alternative Names: MPDL-3280A; RG-7446; RO 5541267; TECENTRIQ

Latest Information Update: 19 Jan 2017

Price : $50

At a glance

  • Originator Genentech; University Medical Center Groningen
  • Developer ARCAGY/GINECO Group; Astex Pharmaceuticals; Chugai Pharmaceutical; Clovis Oncology; Columbia University; Dana-Farber Cancer Institute; European Organisation for Research and Treatment of Cancer; Fondazione Michelangelo; Genentech; Immune Design; Incyte Corporation; M. D. Anderson Cancer Center; Roche; University Medical Center Groningen; University of California at San Francisco; University of California System; Yale University
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD274 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer; Urogenital cancer
  • Preregistration Bladder cancer
  • Phase III Breast cancer; Colorectal cancer; Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Renal cell carcinoma; Small cell lung cancer
  • Phase II Soft tissue sarcoma; Solid tumours
  • Phase I/II Diffuse large B cell lymphoma; Follicular lymphoma
  • Phase I Acute myeloid leukaemia; Malignant melanoma; Multiple myeloma; Myelodysplastic syndromes
  • No development reported Haematological malignancies

Most Recent Events

  • 09 Jan 2017 Preregistration for Bladder cancer (Adjuvant therapy, Neoadjuvant therapy, First-line therapy, Late-stage disease, Metastatic disease) in USA (IV)
  • 09 Jan 2017 The US FDA accepts sBLA for atezolizumab in Bladder cancer (Urothelial carcinoma, Adjuvant therapy, Neoadjuvant therapy, First-line therapy, Late-stage disease, Metastatic disease) (IV)
  • 01 Jan 2017 Genentech initiates enrolment in a phase II trial for Non-small cell lung cancer (First-line therapy) in USA (NCT02927301)
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