Venetoclax

Drug Profile

Venetoclax

Alternative Names: ABT 199; GDC-0199; RG 7601; RO 5537382; Venclexta; VENCLYXTO

Latest Information Update: 18 Jan 2017

Price : $50

At a glance

  • Originator Abbott Laboratories; Genentech; Walter and Eliza Hall Institute of Medical Research
  • Developer AbbVie; Dana-Farber Cancer Institute; Genentech; Nantes University Hospital; Roche
  • Class Antineoplastics; Benzamides; Heterocyclic bicyclo compounds; Piperazines; Pyrans; Pyridines; Pyrroles; Small molecules; Sulfonamides
  • Mechanism of Action Apoptosis stimulants; Proto-oncogene protein c-bcl-2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse large B cell lymphoma; Multiple myeloma; Acute myeloid leukaemia; Chronic lymphocytic leukaemia
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chronic lymphocytic leukaemia
  • Phase III Acute myeloid leukaemia; Multiple myeloma
  • Phase II Diffuse large B cell lymphoma; Non-Hodgkin's lymphoma; Waldenstrom's macroglobulinaemia
  • Phase I/II Follicular lymphoma; Mantle-cell lymphoma
  • Phase I Breast cancer; Systemic lupus erythematosus
  • Preclinical Myelodysplastic syndromes

Most Recent Events

  • 20 Dec 2016 AbbVie plans a phase III trial for Acute myeloid leukaemia in Brazil (NCT02993523)
  • 08 Dec 2016 Registered for Chronic lymphocytic leukaemia (Monotherapy, Second-line therapy or greater) in European Union (PO)
  • 08 Dec 2016 Venetoclax receives Orphan Drug status for Diffuse large B cell lymphoma in European Union
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