Depatuxizumab mafodotin

Drug Profile

Depatuxizumab mafodotin

Alternative Names: ABT-414; ABT-414/806

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Abbott Laboratories
  • Developer AbbVie
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Glioblastoma
  • Phase II Non-small cell lung cancer
  • Phase I Solid tumours

Most Recent Events

  • 25 Apr 2017 AbbVie initiates an expanded access of depatuxizumab mafodotin for Cancer (NCT03123952)
  • 07 Oct 2016 Updated safety and efficacy data from phase I trial presented at the 41st European Society for Medical Oncology Congress (ESMO-2016)
  • 11 Jul 2016 Depatuxizumab mafodotin receives Rare Paediatric Disease designation from the US FDA for Diffuse intrinsic pontine glioma
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