Depatuxizumab mafodotin

Drug Profile

Depatuxizumab mafodotin

Alternative Names: ABT-414; ABT-414/806

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator Abbott Laboratories
  • Developer AbbVie
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Mitosis inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Glioblastoma
  • Phase II Non-small cell lung cancer
  • No development reported Solid tumours

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Solid-tumours in Canada (IV, Infusion)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Solid-tumours in USA (IV, Infusion)
  • 19 Jun 2017 AbbVie completes a phase I trial in Glioblastoma (Combination therapy) in USA, Australia and Netherlands (IV) (NCT01800695)
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