DKN 01

Drug Profile

DKN 01

Alternative Names: DKN-01; LY-2812176

Latest Information Update: 15 Jul 2017

Price : $50

At a glance

  • Originator Eli Lilly
  • Developer Leap Therapeutics
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action DKK1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Multiple myeloma
  • Phase I Biliary cancer; Non-small cell lung cancer; Oesophageal cancer; Solid tumours

Most Recent Events

  • 21 Jun 2017 Leap Therapeutics, in collaboration with Merck plans a phase II trial for Gastric cancer and Oesophageal cancer (Combination therapy, Late-stage disease, Second-line therapy)
  • 02 Jun 2017 Updated efficacy and adverse events data from a phase I trial in Biliary cancer presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 18 May 2017 Updated efficacy data from a phase I trial in Biliary cancer released by Leap Therapeutics
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