DKN 01

Drug Profile

DKN 01

Alternative Names: DKN-01; LY-2812176

Latest Information Update: 15 Jul 2017

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At a glance

  • Originator Eli Lilly
  • Developer Leap Therapeutics
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action DKK1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Multiple myeloma
  • Phase I Biliary cancer; Non-small cell lung cancer; Oesophageal cancer; Solid tumours

Most Recent Events

  • 08 Sep 2017 Leap Therapeutics and European Organisation for Research and Treatment of Cancer plan clinical trials of DKN 01 in combination with atezolizumab +/- paclitaxel in advanced Oesophagogastric malignancies and DKN 01 plus atezolizumab in advanced Biliary tract cancers across Europe in 2018
  • 11 Aug 2017 Leap Therapeutics plans a clinical trial for Gynaecological cancer in second half of 2017
  • 21 Jun 2017 Leap Therapeutics, in collaboration with Merck plans a phase II trial for Gastric cancer and Oesophageal cancer (Combination therapy, Late-stage disease, Second-line therapy) in second half of 2017
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