Drug Profile


Alternative Names: IONIS-APO(a)Rx; IONIS-APOA Rx; ISIS-494372; ISIS-APO(a)RX; ISIS-APOA Rx

Latest Information Update: 14 Dec 2015

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At a glance

  • Originator Isis Pharmaceuticals
  • Class Antihyperlipidaemics; Antisense oligonucleotides
  • Mechanism of Action Apolipoprotein A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Hyperlipoproteinaemias

Most Recent Events

  • 10 Dec 2015 Discontinued - Phase-II for Hyperlipoproteinaemia in Canada, Denmark, Germany, Netherlands, United Kingdom (SC)
  • 08 Nov 2015 Efficacy and adverse event data from a phase II trial in Hyperlipoproteinaemia presented at the American Heart Association Scientific Sessions (AHA-2015)
  • 07 Aug 2014 Phase-II clinical trials in Hyperlipoproteinaemia in Denmark and Germany (SC) (EudraCT2014-000701-13)
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