Drug Profile


Alternative Names: RG-7388; RO-5503781

Latest Information Update: 08 Dec 2017

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At a glance

  • Originator Roche
  • Developer Mayo Clinic; National Cancer Institute (USA); NHS Greater Glasgow and Clyde; Roche; University of Glasgow
  • Class Aminobenzoic acids; Antineoplastics; Pyrrolidines; Small molecules
  • Mechanism of Action Proto-oncogene protein c mdm2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase II Polycythaemia vera
  • Phase I/II Diffuse large B cell lymphoma; Follicular lymphoma; Multiple myeloma; Non-Hodgkin's lymphoma; Prostate cancer
  • Phase I Cancer; Essential thrombocythaemia; Solid tumours

Most Recent Events

  • 27 Nov 2017 Phase-I clinical trials in Solid tumours (In adults, In the elderly, Late-stage disease) in USA (PO) (NCT03362723)
  • 16 Nov 2017 Phase-II clinical trials in Polycythaemia vera (Monotherapy) in Australia (PO) (NCT03287245)
  • 22 Sep 2017 Phase-II clinical trials in Polycythaemia vera (Monotherapy) in USA (PO) (NCT03287245)
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