Metformin controlled-release/sitagliptin - Merck

Drug Profile

Metformin controlled-release/sitagliptin - Merck

Alternative Names: Januet XR; Janumet XR; MK-0431A XR; Sitagliptin/metformin HCl extended-release; Sitagliptin/metformin hydrochloride extended-release

Latest Information Update: 31 Aug 2017

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At a glance

  • Originator Merck & Co
  • Class Antihyperglycaemics; Biguanides; Insulin sensitisers; Pyrazines; Small molecules; Triazoles
  • Mechanism of Action AMP activated protein kinase stimulants; CD26 antigen inhibitors; Gluconeogenesis inhibitors; Glucose modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Marketed Type 2 diabetes mellitus

Most Recent Events

  • 31 Aug 2017 Phase-III development for Type-2 diabetes mellitus (In adolescents, In children) is ongoing in countries worldwide (PO) (NCT01760447) (EudraCT2012-004035-23)
  • 31 Aug 2017 Phase-III clinical trials in Type-2 diabetes mellitus (In adolescents, In children) in Moldova, Mauritius, Greece, Guatemala and Georgia (PO) before August 2017 (NCT01760447)
  • 07 Apr 2017 Merck receives complete response letter from the FDA for metformin controlled-release/sitagliptin treatment of patients with Type 2 diabetes mellitus
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