Drug Profile


Alternative Names: AVP-786; CTP-786; d-DM; Deudextromethorphan Hydrobromide [d6-DM]/Quinidine Sulfate [Q]; Deuterated dextromethorphan plus ultra low dose quinidine; Deuterated DM plus ultra low dose quinidine; Deuterated-dextromethorphan; Deuterated-DM

Latest Information Update: 16 Oct 2017

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At a glance

  • Originator Concert Pharmaceuticals
  • Developer Avanir Pharmaceuticals
  • Class Antidepressants; Antipsychotics; Antitussives; Morphinans; Neuroprotectants; Opioid analgesics; Organic deuterium compounds; Small molecules
  • Mechanism of Action Cytochrome P 450 enzyme system inhibitors; KATP channel inhibitors; NMDA receptor antagonists; Norepinephrine plasma membrane transport protein inhibitors; Serotonin plasma membrane transport protein inhibitors; Sigma-1 receptor agonists; Sigma-1 receptor antagonists; Sodium channel antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Agitation
  • Phase II Brain injuries; Major depressive disorder; Neurodegenerative disorders; Schizophrenia
  • Phase I Neuropathic pain
  • Preclinical Psychiatric disorders

Most Recent Events

  • 01 Aug 2017 Avanir Pharmaceuticals completes a phase II trial in Schizophrenia (Adjunctive treatment) in USA (PO) (NCT02477670)
  • 07 Jun 2017 Phase-II clinical trials in Brain injuries (neurobehavioral disinhibition in traumatic brain injury) in USA (PO)
  • 30 May 2017 Avanir Pharmaceuticals initiates enrolment in a phase II trial in Neurodegenerative disorders (In adults, In the elderly) in USA (PO) (NCT03095066)
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