Drug Profile


Alternative Names: AZD-6094; HMP-504; HMPL-504; Volitinib

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Hutchison MediPharma
  • Developer AstraZeneca; Hutchison MediPharma; National Cancer Institute (USA); Samsung Medical Center
  • Class Antineoplastics; Imidazoles; Pyrazines; Pyrazoles; Pyridines; Small molecules; Triazines; Triazoles
  • Mechanism of Action Proto oncogene protein c met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Adenocarcinoma; Lung cancer; Non-small cell lung cancer; Renal cell carcinoma
  • Phase I Gastric cancer; Solid tumours

Most Recent Events

  • 14 Feb 2017 Safety and efficacy data from the phase II trial in Renal cell carcinoma released by AstraZeneca and Hutchison MediPharma
  • 10 Feb 2017 Phase-II clinical trials in Lung cancer (Second-line therapy or greater, Monotherapy, Late-stage disease, Metastatic disease) in China (PO) (NCT02897479; 9211766)
  • 09 Feb 2017 AstraZeneca in collaboration with Hutchison MediPharma plans a phase III trial in Renal cell carcinoma (Unresectable/Inoperable, Metastatic disease, Late-stage disease) in USA (NCT03091192)
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