Drug Profile


Alternative Names: AZD-6094; HMP-504; HMPL-504; Volitinib

Latest Information Update: 13 Oct 2017

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At a glance

  • Originator Hutchison MediPharma
  • Developer AstraZeneca; Hutchison MediPharma; National Cancer Institute (USA); Samsung Medical Center
  • Class Antineoplastics; Imidazoles; Pyrazines; Pyrazoles; Pyridines; Small molecules; Triazines; Triazoles
  • Mechanism of Action Proto oncogene protein c met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Renal cell carcinoma
  • Phase II Adenocarcinoma; Lung cancer; Non-small cell lung cancer
  • Phase I Gastric cancer; Solid tumours

Most Recent Events

  • 29 Sep 2017 Efficacy and adverse events data from a phase I trial in Gastric cancer (Late-stage disease, Combination therapy, Second-line therapy or greater) released by Hutchison Pharma
  • 06 Sep 2017 AstraZeneca initiates enrolment in a phase I trial in Healthy volunteers in USA (PO) (NCT03258515)
  • 29 Aug 2017 AstraZeneca plans a phase I trial in Healthy volunteers in USA (NCT03258515)
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