Research programme: histone methyltransferase inhibitors - Celgene/Epizyme

Drug Profile

Research programme: histone methyltransferase inhibitors - Celgene/Epizyme

Alternative Names: CARM1 inhibitors; coactivator-associated arginine methyltransferase 1 inhibitors; EPZ 020411; HMT inhibitors; PRMT1 inhibitors; PRMT3 inhibitors; PRMT6 inhibitors; PRMT8 inhibitors; Protein arginine methyltransferase 1 inhibitors; Protein arginine methyltransferase 3 inhibitors; Protein arginine methyltransferase 6 inhibitors; Protein arginine methyltransferase 8 inhibitors

Latest Information Update: 14 Jul 2015

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At a glance

  • Originator Epizyme
  • Developer Celgene International SARL; Epizyme
  • Class Pyrazoles
  • Mechanism of Action Histone methyltransferase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Haematological malignancies; Leukaemia; Solid tumours

Most Recent Events

  • 10 Jul 2015 Celgene and Epizyme extend research collaboration for the development of histone methyltransferase inhibitors
  • 20 Apr 2015 Preclinical trials in Solid tumours in USA (Parenteral)
  • 28 Oct 2014 Preclinical development is ongoing in USA
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