Drug Profile


Alternative Names: GS-4059; ONO-4059

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Ono Pharmaceutical
  • Developer Gilead Sciences; Ono Pharmaceutical
  • Class Antineoplastics; Purines; Pyrrolidines; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Chronic lymphocytic leukaemia; Sjogren's syndrome
  • Phase I/II Lymphoma
  • Phase I B cell lymphoma; Rheumatoid arthritis
  • Preclinical Systemic lupus erythematosus

Most Recent Events

  • 01 Jul 2017 Phase-I/II clinical trials in Lymphoma (Refractory metastatic disease, Monotherapy, Second-line therapy or greater) in Japan (PO) (JapicCTI-173646)
  • 02 Jun 2017 Efficacy and adverse events data from a phase Ib trial in B-cell lymphoma (Combination therapy, Second-line therapy or greater) presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 01 May 2017 Phase-II clinical trials in Sjogren's syndrome (In the elderly, In adults) in USA, United Kingdom (PO) (NCT03100942)
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