Mirvetuximab soravtansine - ImmunoGen

Drug Profile

Mirvetuximab soravtansine - ImmunoGen

Alternative Names: Anti-FOLR1-monoclonal-antibody-maytansinoid-conjugate-IMGN-853; IMGN-853; M9346A-sSPDB-DM4; M9346A-sulfo-SPDB-DM4

Latest Information Update: 18 Jul 2017

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At a glance

  • Originator ImmunoGen
  • Developer ImmunoGen; National Comprehensive Cancer Network
  • Class Antineoplastics; Drug conjugates; Immunoconjugates; Maytansinoids; Monoclonal antibodies
  • Mechanism of Action Folate receptor 1 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Phase II Breast cancer
  • Phase I/II Endometrial cancer
  • Phase I Solid tumours

Most Recent Events

  • 05 Jun 2017 Phase-II clinical trials in Breast cancer (Monotherapy, Newly diagnosed, Second-line therapy or greater, Metastatic disease) in USA (IV) (NCT03106077)
  • 02 Jun 2017 Additional efficacy data from a phase I trial in Ovarian cancer presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 02 Jun 2017 Adverse events data from the phase Ib FORWARD II trial in Ovarian cancer, Peritoneal cancer and Fallopian tube cancer, presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
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