Drug Profile


Alternative Names: INCB-039110; INCB-039110-adipate; INCB-39110; Itacitinib-adipate

Latest Information Update: 29 Sep 2017

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At a glance

  • Originator Incyte Corporation
  • Developer AstraZeneca; Incyte Corporation
  • Class Antineoplastics; Antipsoriatics; Antirheumatics; Small molecules
  • Mechanism of Action Janus kinase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Graft-versus-host disease
  • Phase II Hodgkin's disease; Non-small cell lung cancer
  • Phase I/II Non-Hodgkin's lymphoma; Solid tumours
  • Discontinued Myelofibrosis; Pancreatic cancer; Plaque psoriasis; Rheumatoid arthritis

Most Recent Events

  • 30 Oct 2017 Incyte Corporation plans the phase I GRAVITAS-119 trial for Graft versus host disease (Combination therapy) in USA and Germany in January 2018 (NCT03320642)
  • 07 Sep 2017 Massachusetts General Hospital, Incyte Pharmaceuticals and Sundry plan a phase I trial for Malignant melanoma and Solid tumours (Combination therapy) in USA (NCT03272464)
  • 10 Aug 2017 Chemical structure information added
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