Selinexor

Drug Profile

Selinexor

Alternative Names: CRM1 nuclear export inhibitor KPT-330; KPT-330; KPT-330-003; SINE - Karyopharm Therapeutics; SINE KPT 330

Latest Information Update: 22 Mar 2017

Price : $50

At a glance

  • Originator Karyopharm Therapeutics
  • Developer Cardiff University; Dana-Farber Cancer Institute; Erasmus MC; H. Lee Moffitt Cancer Center and Research Institute; Karyopharm Therapeutics; Lymphoma Academic Research Organisation; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (USA); National University Hospital (Singapore); Rigshospitalet; Sheba Medical Center; St. Jude Childrens Research Hospital; The Ohio State University Comprehensive Cancer Center; University of Chicago; University of Texas M. D. Anderson Cancer Center; University of Texas Southwestern Medical Center; Weill Cornell Medical College
  • Class Acrylamides; Antineoplastics; Hydrazines; Pyrazines; Small molecules
  • Mechanism of Action Exportin-1 protein inhibitors; Nuclear export inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse large B cell lymphoma; Acute myeloid leukaemia; Chronic lymphocytic leukaemia; Multiple myeloma; Soft tissue sarcoma
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Multiple myeloma
  • Phase II/III Liposarcoma
  • Phase II Acute myeloid leukaemia; Breast cancer; Cervical cancer; Cutaneous T cell lymphoma; Diffuse large B cell lymphoma; Endometrial cancer; Glioblastoma; Myelodysplastic syndromes; Neuroendocrine tumours; Ovarian cancer; Peripheral T-cell lymphoma; Prostate cancer; Small cell lung cancer; Squamous cell cancer; Thymoma
  • Phase I/II Acute lymphoblastic leukaemia; Chronic myelomonocytic leukaemia
  • Phase I B cell lymphoma; Chronic lymphocytic leukaemia; Colorectal cancer; Diabetic foot ulcer; Gastric cancer; Malignant melanoma; Non-Hodgkin's lymphoma; Oesophageal cancer; Rectal cancer; Solid tumours
  • Preclinical Myelofibrosis; Non-small cell lung cancer
  • Research Osteosarcoma

Most Recent Events

  • 14 Mar 2017 Phase-III clinical trials in Multiple myeloma (Combination therapy, Early-stage disease, Second-line therapy or greater) in Austria (PO) (EudraCT2016-003957-14)
  • 14 Mar 2017 Phase-III clinical trials in Multiple myeloma (Combination therapy, Second-line therapy or greater, Early-stage disease) in Hungary (PO) (EudraCT2016-003957-14)
  • 10 Mar 2017 The US FDA places all clinical trials of selinexor on partial clinical hold
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